In 2 U.S multi-center studies, it has been shown that patients who received PerioChip®after scaling and root planing (SRP) experienced a statistically significant reduction in the depth of their periodontal pockets versus patients who were treated with SRP alone, at 9 months after initial treatment.
Approximately twice as many subjects treated with PerioChip®+ SRP showed an improvement in pocket depth of 2 mm or more at 9 months compared to subjects treated with SRP alone (36% (PerioChip® + SRP) vs. 17% (SRP alone) in Study 94-002 and 25% (PerioChip®+ SRP) vs. 10% (SRP alone) in Study 94-003).
- The two studies were double-blind, randomized, controlled clinical trials that included 447 adult patients with periodontitis who had at least 4 pockets with probing depth of 5-8 mm that bled on probing.
- All patients received full mouth SRP at baseline and if the pocket depth remained ≥5 mm at 3 and/or 6 months after initial treatment, another chip was placed into the pocket.
- Patients were in good general health.
- Diabetics were excluded from the studies.
- Patients did not have acutely abscessed periodontal pockets.
- PerioChip® effects on bleeding upon probing have not been established.
- There were no significant changes in plaque development or gingivitis.
- Smokers and non-smokers were enrolled in these studies ;although non- smokers using PerioChip® demonstrated significant improvement in PD, smokers demonstrated a trend towards improvement that did not reach statistical significance.